Microglia in the brain’s parenchyma arise from macrophage progenitors in the embryonic yolk sac (Ginhoux et al., 2010), and are thought to self-renew locally during a mammal’s lifespan, without ...
Key insight: The glymphatic system flushes amyloid plaques primarily during deep NREM sleep. Disruptions to sleep architecture — whether caused by ageing, inflammation, or vascular stiffness — reduce ...
Anatomy explorers have charted a new path myeloid cells use to access the brain. On 3 June in Neuron, scientists led by Lindsay Hohsfield and Kim Green, both at the University of California, Irvine, ...
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