Members of the CD44 transmembrane protein family have functions in many processes in normal life (for example, in haematopoiesis, the immune system and organogenesis), and in pathological situations ...

CD44, the major hyaluronan (HA) receptor, makes abundant use of alternative splicing and can be located in glycolipid-enriched microdomains (GEMs). The extracellular and the cytoplasmic domains can ...

The molecule called CD44 is a transmembrane glycoprotein involved in cell to cell adhesion, interactions, and signaling. It is also a receptor of hyaluronic acid (HA) which is mechanistically involved ...

Due to their rapid metastatic spread, pancreatic tumors are among the most aggressive types of cancer. Only three to five percent of patients have a survival rate of five years. A team of researchers ...

Does knowledge guide practice? Another look at the management of non-small-cell lung cancer. CD44 is a hyaluronic acid receptor that exists as a standard 90-kd form (CD44S) as well as several CD44 ...

Protein biosignature identified by LC-MS/MS in classifying breast cancer and predicting tumor response to neoadjuvant therapy. Methods: Histological analysis of the breast was carried out on mounted ...

A multi-disciplinary approach was employed, using a combination of multiomic techniques, including single-cell RNA-sequencing ...

Glioblastoma (GBM) is the most aggressive and lethal form of brain cancer, with a median survival of only 15 months despite intensive treatment. Current therapies—including surgery, radiation, and ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity. A ...

Regulatory mechanisms governing stem cell quiescence in glandular organs remain ill-defined. Here, multi-omics profiling ...

Studies in mice and humans show fibroblasts that overexpress HAS2 develop an aggressive phenotype. Scientists have implicated an interplay between overexpression of hyaluronan synthase 2 (HAS2) and ...

Hyaluronan is a polyanionic, megadalton-scale polysaccharide, which initiates cell signaling by interacting with several receptor proteins including CD44 involved in cell-cell interactions and cell ...