Entering Sunday's showdown against the New England Patriots, the Buffalo Bills' most likely first-round playoff opponent is the Pittsburgh Steelers.

Additionally, if the Houston Texans make the postseason as the No. 7 seed, they very well could beat the Patriots/Broncos in the wild card round, creating a final four in the AFC of the Bills, Texans, Jacksonville Jaguars, and Los Angeles Chargers, should the AFC playoff teams remain as they currently sit.

The Bills had a massive win against the Bengals on Sunday, putting Buffalo in position for the No. 5 seed and the first wild-card spot. There are still four weeks left in the season, and the Bills could very well win the AFC East.

The Bills hold the No. 5 seed in the AFC. Here's a look at the latest playoff odds, updated AFC playoff picture and remaining schedule.

The 2025 NFL playoff picture became clearer Sunday night, with the Kansas City Chiefs' chances of making the postseason and a fourth, consecutive Super Bowl seemingly dashed by the Houston Texans.

Buffalo and Kansas City are in jeopardy of having their division championship streaks snapped. The Bills, who have won five straight AFC East titles, trailed the New England Patriots by 1.5 games. Kansas City, winner of nine consecutive AFC West crowns, are in third place, 3.5 games behind Denver.

The playoff picture is starting to take shape, and if the postseason started today, the Buffalo Bills would be hitting the road for a wild card game.

If the season ended today, the Patriots would win their first AFC East title since the 2019 season and the Bills would have to enter the playoffs as a wild card team. To make matters worse, Stefon Diggs had his best game of the year against his old team.