You may think of bile acids only in relation to digestion, especially after eating fatty foods, but they also play a crucial ...

The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut ...

Bile acids long have been known to play a role in human metabolism. Synthesized from cholesterol in the liver, bile acids are involved in digestive processes, particularly in absorbing fat. They also ...

Bile acids, synthesised from cholesterol in the liver, are central to lipid digestion but also serve as signalling molecules that regulate metabolism, inflammation and cellular homeostasis. In ...

Habegger is a professor in the UAB Department of Medicine Division of Endocrinology, Diabetes and Metabolism and also a scientist in the UAB Nutrition Obesity Research Center who studies how glucagon ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

Liver is the major organ for metabolism of sulfur amino acids (methionine, cysteine, taurine) and expresses high levels of sulfur amino acid synthesis and metabolising enzymes. Dietary intake, ...

Over the years, researchers have amassed strong evidence that caloric restriction can extend lab animals’ lives. Unfortunately, extending those benefits to humans has proved difficult, in part because ...