A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. AD, a representative form of senile dementia, occurs ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, ...

Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that inhibition ...

Long COVID was associated with persistent immune and endothelial dysfunction, with increased necroptosis and autophagy linked ...

A complex cellular process called autophagy is the topic of a major new textbook which encapsulates over 30 years of research in this growing field of study. A complex cellular process called ...

They demonstrated that C53-mediated autophagy was conserved among eukaryotes and that C53 co-evolved with the UFMylation pathway. Molecular remnants or the existence of related proteins indicated that ...

Drug resistance remains one of the greatest obstacles to successful treatment of gastric cancer, limiting the long-term ...

A deeper understanding of how key cellular processes interact is reshaping perspectives on diabetes and its wide-ranging ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...