Clinical studies have shown that periodontal disease with Aggregatibacter actinomycetemcomitans can exacerbate symptoms of rheumatoid arthritis (RA), but the molecular mechanisms behind this remain ...

In this study, we describe new features of human macrophage cell death induced by A. actinomycetemcomitans leukotoxin that that can be linked to pathogenic mechanisms of inflammatory-related diseases.

Researchers at Tokyo Medical and Dental University have found that the periodontal bacterium Aggregatibacter actinomycetemcomitans exacerbates rheumatoid arthritis through inflammasome activation.

Tokyo: Periodontal disease, which affects the gums and tissues around the teeth, is one of the most common dental disorders globally. Periodontal disease, which is most commonly caused by the growth ...