Terpenoid cyclases catalyze the most complex reactions in biology, in that more than half of the substrate carbon atoms often undergo changes in bonding during the course of a multistep cyclization ...

Timothy J. Wilson, Nan-Sheng Li, Jun Lu, John K. Frederiksen, Joseph A. Piccirilli, David M. J. Lilley, Olke C. Uhlenbeck Proceedings of the National Academy of ...

General acid or general base catalysis is used by enzymes to facilitate the proton transfers required in biochemical transformations. This catalytic mechanism requires that enzymes position ...

Bifunctional acid−base catalysts are highly desirable for industrially relevant chemical processes. Owing to their ability to activate electrophiles and nucleophiles simultaneously, they allow the ...