Researchers have discovered an unusual case where two well-known cancer-related mutations—APC and KRAS—coexisted in a woman with familial adenomatous polyposis (FAP) and a history of endometrial ...

Familial adenomatous polyposis (FAP) is caused by mutations in the APC gene and 2 different, or biallelic mutations, in the MUTYH gene. However, not all patients with colorectal polyposis are found to ...

The order of cancer-driving mutations—genetic changes—plays an important role in whether tumors in the intestine can develop, new research reveals. These are the findings published on 3 December in ...

Researchers have discovered an unusual case where two well-known cancer-related mutations-APC and KRAS-coexisted in a woman with familial adenomatous polyposis (FAP) and a history of endometrial ...

Recently, a collaborated research group from Hefei Institutes of Physical Science (HFIPS) of Chinese Academy of Sciences (CAS) and The Second Hospital of Anhui Medical University dissected, for the ...

The model suggests that negative KRAS findings are believable when the maximum of APC and TP53 frequencies is at least 8% (corresponding posterior probability of false negative <5%). Validation ...

Tumor-associated DNA has been detected, using various techniques, in the plasma of colorectal cancer (CRC) patients, including DNA with mutations in APC, TP53, and K-RAS. We report a highly sensitive ...

Prospective BASECAMP-1 experience in patients with gastrointestinal (GI) cancer: Identifying patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH) for a future therapeutic trial ...