Aging is accompanied by widespread epigenetic reprogramming, including the loss of heterochromatin and altered chromatin-associated processes. These changes compromise transcriptional precision and ...
A recent study has uncovered how the pathogen Ralstonia solanacearum disrupts plant defenses through its type III effector RipAF1. The research shows that RipAF1 modifies a critical plant protein, ...
A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of ...
Although scientists discovered PARP1's role in ADP-ribosylation of proteins about 60 years ago, O'Sullivan and his collaborator, Ivan Ahel, Ph.D., professor in the Sir William Dunn School of Pathology ...
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