The week 13 matchup between the Oregon Ducks and the USC Trojans will be the 65th meeting between the two longtime foes. The rivalry between Oregon and USC ext

One of the most intriguing and consequential games of the college football weekend kicks off Saturday afternoon in Eugene, OR where the 6th-ranked Ducks host the No. 16 Trojans of USC (8-2). There are significant College Football Playoff implications for both teams.

Whose defense will step up in the USC-Oregon game? USA TODAY's Jordan Mendoza and The Register-Guard's Alec Dietz break it down.

The No. 15 USC Trojans will play the No. 7 Oregon Ducks on Saturday, Nov. 22, and a College Football Playoff appearance could be at stake for both teams. USC co

Throughout the 2025 campaign, the Oregon Ducks have continued making their rounds of meeting Big Ten opponents for the first time as a member of the conference, often with select matchups prior to then. But in Week 13 against the USC Trojans, that won't be the case.

The No. 5 Oregon Ducks (9-1) meet a conference opponent when they host the No. 16 USC Trojans (8-2) on Saturday, November 22, 2025 at Autzen Stadium in a Big Ten showdown. Curious about which team we predict will come out on top in this matchup? Find out below.

Joel Klatt joins Colin Cowherd to discuss Miami’s issue with Notre Dame being ranked higher than them, whether or not Texas has a chance at the playoffs after losing 35-10 to Georgia, and USC’s odds of beating Oregon.

Best College Football Playoff contender betting picks at FanDuel: Combine these three picks involving Texas-Arkansas, USC-Oregon, BYU-Cincinnati for a +679 payout

The last time these teams met as ranked foes was 2015, which was the 10th straight such meeting. They split those 10 games.

The No. 17 USC Trojans, coming off a 26-21 win over the No. 21 Iowa Hawkeyes, will face their biggest test of the season on the road against the No. 8 Oregon Du