The Week 12 NFL schedule is headlined by the ever-continuing saga of the Kansas City Chiefs against the AFC South-leading Indianapolis Colts on Nov. 23. Kansas City is 5-5 after losing on a last-second field goal at Denver and returns home in need of a run.

As we know, the game of football isn't played on paper, but the Indianapolis Colts' strength of schedule coming out of the bye week ranks as one of the more difficult in the NFL. According to ESPN's Football Power Index, the Colts' strength of schedule over their remaining seven games is the second toughest.

In Sporting News' picks and predictions for Week 13, the red-hot Texans deal the Colts another loss in a key AFC South showdown while the Shedeur Sanders show in Cleveland screeches to a halt.

What channel is Chiefs vs. Colts on today? Live stream, time, TV schedule to watch NFL Week 12 game originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. MVP-caliber talents are set to clash atop the Arrowhead Stadium turf.

The Colts have emerged as one of the top teams in the NFL through 11 weeks, but they will be challenged as they face the most difficult schedule among AFC teams over the final seven weeks. Every opponent remaining is .500 or better. So far this season, the Colts are 2-2 in games against teams that are currently .500 or better.

SportsLine expert Larry Hartstein breaks down how bettors and sportsbooks fared in Week 12 of the 2025 NFL season

Welcome to The Athletic 's coverage of Week 12 in the NFL. Earlier today, the Kansas City Chiefs kept their playoff hopes alive with a 23-20 win over the Indianapolis Colts. In the afternoon window, the Dallas Cowboys shocked the Philadelphia Eagles in a 24-21 comeback win.