Buffalo is a 14.5-point favorite in the latest Saints vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 48.5. The Bills are -1493 money line favorites (risk $1,

Nik Bonitto is on fire to start the season. Bonitto, who turned 26 years old last week, has four sacks in four games and has been one of the best edge rushers in the NFL. His four-year, $106 million extension signed before the season might be a bargain.

Two more games remain on Monday night, but the odds are out for Week 5, and it’s time to do some early prognosticating.

High expectations have their price, leaving Josh Allen and the Buffalo Bills unhappy, but relieved, following a close call against the winless New Orleans Saints.

The first version of this column excoriated the Buffalo Bills. It ripped them from one side to the other for an offense that seemed to think the game was over at 14-7 and a defense that couldn’t stop a New Orleans Saints rushing offense that came into the day ranking among the 10 worst in the league.

The Buffalo Bills are one of only two teams in the NFL still with an unblemished record in 2025. After defeating the New Orleans Saints (0-4) in Week 4 in a 31-19 final, the Bills and Philadelphia Eagles are the only two sides still sitting at 4-0.

The Buffalo Bills and Philadelphia Eagles remain undefeated and top the Week 5 NFL power rankings. The Miami Dolphins are ranked 29th ahead of their Monday night game against the New York Jets. Joe Schad's rankings place the New Orleans Saints and Tennessee Titans at the bottom of the league.

New Orleans Saints running back Kendre Miller speaks with the media from the Ochsner Sports Performance Center on Monday, September 29, 2025 the day after the Saints' Week 4 game against the Buffalo Bills and ahead of Week 5 against the New York Giants.