But not all is lost, depending on how you look at the situation.

Our fantasy football IR report and tracker for injured NFL players on injured reserve in Week 4 of 2025. Fantasy football injury updates reports for James Conner, Najee Harris, Tyjae Spears, Brandon Aiyuk,

For Conner, it was his second right MCL injury in two years, going back to his college days. The injury ended his rookie year as he was put on IR, missing the final two regular season games and a playoff game. He appeared in a total of 14 games in 2017.

Arizona Cardinals RB James Conner took to social media on Tuesday to share a few words following news of his season-ending injury after being carted off with a foot injury in Week 3.

Week 4 opened with Thursday night's battle between the Seattle Seahawks and Arizona Cardinals. With James Conner out for the year, the Cardinals—and many fantasy managers—turned to backup running back Trey Benson for the week.

Second-year running back Trey Benson is set to take on a heavy workload following James Conner's injury. Benson is slated to make the second start of his career Thursday night against the Seattle Seahawks.

As Ollie Gordon II may know, James Conner is down for the count. After suffering a gruesome ankle injury, the Arizona Cardinals running back is slated to miss the season.

With James Conner out for the season, we look at 5 players the Arizona Cardinals could soon target in free agency or a trade.