Fantasy football relevant injuries and their impact, weather reports and game previews. Plus, Ciely's Week 5 player rankings and more.

Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

Dan's fantasy football start 'em, sit 'em picks for Week 5 of 2025. He looks at potential warning signals from Isiah Pacheco, Jacory Croskey-Merritt, Demarcus Robinson, Khalil Shakir, and Hunter Henry.

Prior to making any waiver wire moves for Week 5, check out our tight end suggestions below. See the list below for potential fantasy football targets you might be able to grab off of the waiver wire this week. Check out the full NFL schedule on FOX Sports!

Fading Indianapolis may also be part of a greater NFL survivor pool strategy, which sees the Colts play a struggling Titans team in a couple of weeks. The model projects the Colts to win 74% of the time, which is lower than other teams this week, making Indianapolis a team to avoid in NFL survivor pool picks. See which team to pick instead here .

Sam Farmer makes his picks and predictions for NFL Week 5, with the Eagles defeating the Broncos, the Rams beating the 49ers and the Chiefs winning on Monday.