The Buffalo Bills took care of business in Week 4, defeating the New Orleans Saints in a matchup that Buffalo didn’t have well in hand until late in the fourth quarter. New Orleans was ready to give the Bills all they could handle, which manifested in a physical game at all levels.

The Buffalo Bills were short on defense due to injuries, but one of their Day 3 draft selections stepped up and was named among the NFL’s biggest winners

Expert recap and game analysis of the Buffalo Bills vs. New Orleans Saints NFL game from September 28, 2025 on ESPN.

Well, that was sloppy, and stressful… and a lot closer than the scoreboard showed. But the Buffalo Bills are 4-0 after their win over the New Orleans Saints on Sunday. It’s the first time since 2020 that they’ve been perfect after four weeks.

The Bills lead the league in multiple categories, including rushing yards per game (163.0), rushing yards (489) and rushing touchdowns (7). They are fifth in passing yards (771) and Josh Allen has only taken four sacks and has yet to throw an interception.

The Buffalo Bills made a historic announcement regarding running back James Cook during their game against the New Orleans Saints.

Two more games remain on Monday night, but the odds are out for Week 5, and it’s time to do some early prognosticating.

Buffalo is a 14.5-point favorite in the latest Saints vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 48. The Bills are -1562 money line favorites (risk $1,562 to win $100),

Bernard missed one play before re-entering the game and making an immediate impact. Bernard stopped running back Alvin Kamara for a 2-yard gain on his first play back in. On the next play, Bernard blitzed, forcing New Orleans quarterback Spencer Rattler to throw the ball into the ground.