Acqui Terme is a city and comune in the province of Alessandria, Piedmont, northern Italy. It is about 35 kilometres south-southwest of …Acqui Terme is a city and comune in the province of Alessandria, Piedmont, northern Italy. It is about 35 kilometres south-southwest of Alessandria. It is one of the principal winemaking communes of the Italian DOCG wine Brachetto d'Acqui.